POSTER
ACTIVITY (15-20 minutes)
Go to the Bookshelf.
Use Entrez to search for information about the clinical manifestations,
and the cellular, molecular and biochemical basis of the phenotype, condition
or disease you have chosen. There is no minimum or maximum number of searches
to do, or references to use - in the real world, the only criterion of
quality is to do as much as necessary to do the job right.
Information of interest includes the following:
-
The aberrant phenotype.
-
Clinical treatment and prognosis.
-
The function of the relevant protein. An explanation
of how
and
why it produces the
aberrant phenotype.
-
A description of the aberrant structure (changes
in primary, secondary and tertiary structure) of the protein.
-
An explanation of how and
why
the aberrant structure of the variant changes the function of the protein.
-
An explanation of how and
why
the defective function of the variant results in the aberrant phenotype.
Examine and compile all relevant hits. Print
all information which you think may be useful for your Poster, and save
it for later use.
Create a bibliography of sources from the Bookshelf.
Print
the
bibliography and hand it in to your instructor. |