Introduction to Genomics
barnes@mail.clarion.edu
Send questions or comments to Dr. Barnes!
Coding DNA
Non-coding
DNA (also known as selfish, ignorant, parasitic and incidental DNA):
makes up approximately 97% .of the human genome .....
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Non-repetitive
"junk" DNA
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Repetitive
Sequences ......... make up at least 50% of the human genome
.......
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Transposable Elements
---------45% derives from such transposons
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Transposons
(move as DNA)
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Retroposons
(Retrotransposons) (move as RNA intermediates)
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Viral-like
Retroposons (terminal LTRs)
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Nonviral-like
Retroposons (lack LTRs).
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LINEs
(Long Interspersed Nuclear Elements)
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SINEs
(Short Interspersed Nuclear Elements)
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Tandem Repeats
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Satellites
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Mini-satellites
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VNTRs
Micro-satellites
Teleological
Implications of Genomic Knowledge ( a possibly inflammatory peronal
opinion)
Genomics
Genome sequencing projects
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8 Eukaryotic genomes
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67
Prokaryotic Genomes
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Agrobacterium tumafasciens
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Bacillus subtilis
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Escherichia coli K12
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Haemohilus influenzae
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Helicobacter pylori
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Pseudomonas aeruginosa
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Salmonella typhimurium LT2
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Yersinia pestis
Proteomics
Structural Biology
Phylogenetic Analysis and Evolution
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