Course Description
The ability to manipulate organisms genetically has been revolutionized
in the last ten years. Biological information produced by this revolution
is represented in many forms: sequence data, structural data, and functional
data. These data can often be accessed and interpreted only with the help
of computers. Data Mining is now an established tool for predicting structure
and understanding function in genomics and proteomics. It is becoming
impossible for molecular biologists and biochemists to do research without
the aid of computer based tools. The advent of computational biology
also offers new opportunities for those in chemistry, physics, mathematics
and computer science.
This course is intended for students in molecular biology, cell biology,
microbiology, physiology, biochemistry, chemistry, physics, mathematics
or computer science. It is an introduction to the concepts, and the principal
data bases and algorithms, of bioinformatics and structural biology/chemistry.
Although emphasis is placed on practical applications, an understanding
of the mathematical basis of the algorithms, and their strengths and weaknesses
- and the important principles of molecular biology and structural chemistry
which they model, is important. This course should enable students to access
and analyze sequence and structure data, create and edit images of molecules,
and present results in web pages, CHIME and Power Point formats.
Prerequisites:
Biology 201 or 203; CIS 110 or 217; Math 260 and 221. Exceptions by permission
of the instructor.
Glossaries of Biotechnology
and Genomics. As with any technical field, biotechnology
is replete with a terminology all its own. These are some glossaries
to terms you may not be familiar with.
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Reference Sources on Molecular Biology,
Genomics and Bioinformatics
Index of DOE primers
- Genomics 101: A Primer
- The Human Genome Project: 1990-2003
- Early Insights from the Human DNA Sequence
- Medicine and the New Genetics
- Other Anticipated Benefits of Genetic Research
- Societal Concerns Arising from the New Genetics
- Beyond the Human Genome Project -- What's Next?
- Genomes to Life: A DOE Systems Biology Program
- Genomes to Life: Putting Microbes to Work
- Dictionary of Genetic Terms |
A
suite of primers from ORNL
(Oak Ridge National Laboratory) |
![](primer-NCBI_small.GIF) |
A suite of primers
from NCBI
(National Center for biotechnology Information) |
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TEXTS
![](bioinformatics_mount.GIF) |
Bioinformatics:
Sequence and Genome Analysis, 2nd edition
David W. Mount,
Cold Spring Harbor Laboratory Press; 2004
ISBN: 0879696877
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![](bioinformatics_practical.GIF) |
Bioinformatics:
A Practical Guide to the Analysis of Genes and Proteins, 3rd edition
Andreas D. Baxevanis
(Editor), B. F. Francis Ouellette (Editor), Wiley-Interscience; 2004
ISBN: 0471478784
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![](bioinformatics_dummies.GIF) |
Bioinformatics
for Dummies, 1st edition
Jean-Michel Claverie,
Cedric Notredame, Jean-Michel Claverie,
Cedric Notredame, For Dummies;
2003
ISBN: 0764516965
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![](bioinformatics_krane.GIF) |
Fundamental
Concepts of Bioinformatics , 1st edition
Dan E. Krane, Michael
L. Raymer , Benjamin Cummings; 2002
ISBN: 0805346333
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![](bioinformatics_skills.JPG) |
Developing
Bioinformatics Computer Skills
Cynthia Gibas, Per
Jambeck, O'Reilly & Associates
ISBN: 1565926641
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![](bioinformatics_discover.GIF) |
Discovering
Genomics, Proteomics, and Bioinformatics
A. Malcolm Campbell,
Laurie J. Heyer , Benjamin Cummings; 2002
ISBN: 0805347224
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