Summary of Cholinergic Pathology and Therapy in AD

• Alzheimer’s disease is associated with impairment of the cholinergic nervous system(1)

• This leads to:
  • decrease in ACh(1)
  • decrease in specific subtypes of nicotinic cholinergic receptors(2)

• Targeting the cholinergic nervous system with:
  • AchE inhibition and
  • nicotinic stimulation/modulation
    may be the optimal cholinergic therapy (3)

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