Pharmacological Comparison of Aricept, ReminylŽ and ExelonŽ

Aricept Reminyl Exelon

Chemical class Piperidine Alkaloid Carbamate

Mechanism Reversible Reversible Pseudo- irreversible

Half-life ~70 h 5.8 h ~2 h*

Hepatic monitoring No No No

Dosing qd bid bid

*Apparent long duration of action (~10 h) due to slow-binding and time-dependent inhibitory kinetics of carbamates

Previous slide

Next slide

Back to first slide

View graphic version