PATHOPHYSIOLOGY OF AGGRESSIVITY IN ALZHEIMER’S DISEASE
Evidence of derangement of serotonergic system:
(1) Clinical response to serotonergic agents (trazodone, tryptophan, bupsirone, sertraline, fluoxetine) in dementia
(2) Depleted levels of serotonergic binding in neocortex (frontal & temporal) found in Alzheimer’s Disease
(3) Intense neurofibrillary tangle information found in dorsal raphe nucleus