Evidence supporting the importance of enhancing nicotinic receptor function in AD
- AD patients have a reduced number of selected subtypes of nicotinic receptors(1)
- Nicotinic receptor antagonists lead to cognitive impairment(2)
- Stimulation of nicotinic receptors may enhance cognitive functions such as memory and learning(3)
- Motor functions are also improved upon nicotinic receptor modulation(4)
- Nicotinic stimulation may be neuroprotective(5)