Nicotinic acetylcholine receptors (nAChR) in the brain
?4?2 nAChR subtype-High affinity
- Pre- and postsynaptic nAChR(3)
- Major excitatory neuronal nAChR(3)
?7 nAChR subtype-Low affinity
- Predominantly presynaptic nAChR(1)
- Generates fast calcium currents(1)
- Affects release of glutamate, 5HT, ACh(2)