Richard Single conducts research in the area of statistical genetics which involves population genetic analyses, comparative genomics, methods for disease association studies, determining properties of measures of overall linkage disequilibrium (LD), and tests for LD and Hardy-Weinberg equilibrium at the individual haplotype/genotype level. An emphasis on the human Major Histocompatibility Complex (MHC) of chromosome 6 has led to the study of microsatellite and SNP markers that are predictive of classical HLA genes due to their influence on the immune response for bone marrow transplantation. He also works in the areas of program evaluation and medical biostatistics with faculty members in the College of Education and Social Services and the College of Medicine.